Protein Details: Potassium voltage-gated channel subfamily D member 3

Protein ID

ICDB_Pro_1044

Protein Name

Potassium voltage-gated channel subfamily D member 3

Gene Name

Kcnd3

Organism

Rattus norvegicus (Rat)

Length

655 amino acids

AlphaFoldDB

AF-Q62897-F1-model_v4.pdb

Function

Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits

Sequence

MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMDDNESENNQESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEHMGKTTSLIESQHHHLLHCLEKTTGLSYLVDDPLLSVRTSTIKNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHSGLTTTCCSRRSKKTTHLPNSNLPATRLRSMQELSTIHIQGSEQPSLTTSRSSLNLKADDGLRPNCKTSQITTAIISIPTPPALTPEGESRPPPASPGPNTNIPSITSNVVKVSVL

PDB Structures

2I2R

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

104;131;132

Disease

Location

Highly expressed in brain; in particular in the retrosplenial cortex; medial habenula; anterior thalamus; hippocampus; cerebellum and lateral geniculate and superior colliculus (PubMed:8734615; PubMed:9001401; PubMed:9450548). Highly expressed in heart atrium (at protein level) and throughout the ventricle wall; in lung and vas deferens (PubMed:8734615; PubMed:8831489; PubMed:9450548).

DOI ID

10.1161/01.res.79.4.659; 10.1152/jn.1996.75.5.2174; 10.1016/s0014-5793(96)01388-9; 10.1016/s0014-5793(97)01483-x; 10.1074/jbc.m101058200; 10.1161/01.res.81.4.533; 10.1038/35000592; 10.1074/jbc.m203651200; 10.1073/pnas.022509299; 10.1152/ajpcell.00293.2004; 10.1161/circresaha.108.191007; 10.1038/ncomms1871; 10.1038/nsmb1164

RefSeq

NP_001257891.1; NP_001257892.1; NP_113927.2 [Q62897-3]